Classification of
Lipids
Lipids are fats that have important roles in
the body.
Although most people think that fat is harmful
to health, the truth is that fat is important to life.
Fat provides energy and depending on the
classification of lipids, it plays an important role in metabolism.
What Are Lipids?
Lipids
are insoluble organic compounds that consist of fat and oil.
The chemical composition of these molecules
includes hydrogen, carbon, and oxygen.
They provide high energy and perform three
important biological functions in the body:
- to provide structure to cell membranes,
- to store energy, and
- to function as signaling molecules.
The classification of lipids includes
phospholipids, triacylglycerols, and sterols.
What Are the Functions of Lipids in the Body?
Lipids play
important roles in the normal function of the body:
· To serve as structural building materials for cell membranes and
organelles
· To provide energy for the organisms, which is greater than what’s
provided by carbohydrates or proteins.
· To serve as signaling molecules and molecular messengers in the
body.
However, lipids also
serve as biomarkers of certain diseases and play some role in genetic
modification and chronic disease.
What Are the Food Sources of Lipids?
Lipids or
fats are macronutrients that are important in human nutrition.
They are found mainly in dairy foods and meats,
as well as other foods.
Rich sources of dietary fats include soybeans,
nuts and seeds, olives, and avocados, which contain essential fatty acids
(EFAs).
Contrary to popular belief, lipids are an
important part of our diet, and a minimum intake is necessary.
However, many health problems are linked to
excessive dietary fat intake, such as obesity, heart disease, and cancer.
Simple
lipids are esters of fatty acid linked with various alcohols.
· Fats and
oils (triglycerides, triacylglycerols)
These esters of fatty acid have glycerol, a
trihydroxy alcohol.
Triglycerides are abundant and constitute about
98 percent of all dietary lipids. The rest consists of cholesterol, its esters
and phospholipids.
Unlike carbohydrates, which can be stored only
for a short time in the body, triglycerides are stored in the body in large
amounts as body fat, which can last for years.
An average man weighing about 70 kg, has at
least 10 to 20 percent of his body weight in lipid, most of which is
triacylglycerol. This is found in adipose (fat) tissue, as well as all other
organs of the body. Body fat is a reservoir of chemical energy.
· Waxes
Waxes are long-chain saturated and unsaturated
fatty acid esters with monohydroxy alcohols, which have high molecular weight.
Waxes are produced naturally by skin glands as
a protection, to keep it lubricated, pliable, and water-proof. Wax also covers
hair, feathers, and wool.
2. Compound
Lipids or Heterolipids
Heterolipids
are fatty acid esters with alcohol and additional groups.
· Phospholipids
(phosphatids)
Phospholipids contain fatty acids, glycerol,
nitrogen bases, phosphoric acid, and other substituents.
They are most abundant in cell membranes and
serve as structural components. They are not stored in large quantities.
As their name implies, phospholipids contain
phosphorus in the form of phosphoric acid groups.
Their molecular structure is polar, consisting
of one hydrophilic head group and two hydrophobic tails.
· Glycolipids
(cerebrosides)
Glycolipids are fatty acids with carbohydrates
and nitrogen but without phosphoric acid.
Glycolipids also include some compounds like
sulfolipids, gangliosides, and sulfatids which are structurally-related.
These cerebrosides are important constituents
of the brain and other tissues. They consist of at least one sugar unit, so
they are also called glycosphingosides.
They are like phospholipids because they have a
hydrophobic region, with a polar region and two long hydrocarbon tails.
Like phospholipids, glycolipids form lipid
bilayers that are self-sealing and form the structure of cellular membranes.
.
3. Derived Lipids
These
substances are derived by hydrolysis from compound and simple lipids. These
fatty acids include alcohols, mono- and diglycerides, carotenoids, steroids,
and terpenes.
· Steroids
The steroids are biological compounds that are
some of the most studied types of fat. They contain no fatty acids and unlike
fats, are nonsaponifiable (cannot be hydrolyzed to yield soap).
· Cholesterol
Cholesterol is a well-studied lipid, because of
its strong correlation with the incidence cardiovascular disease.
It is an important component of cell membranes
and plasma lipoproteins, and is an important precursor of many biologically
important substances like bile acids and steroid hormones.
It is abundant in nerve tissues and is
associated with gallstones.
Dietary cholesterol is found in saturated fats
of animals (as butter and lard), but vegetable oils do not contain cholesterol.
Only a small portion of your body cholesterol
comes from the diet. Most of it is produced in the body.
Eating unsaturated fatty acids from vegetable
oil helps lower blood cholesterol levels by reducing cholesterol synthesis in
the body.
However, eating saturated fats from animal fat
elevates blood cholesterol and triglycerides and reduce the ratio of your good
to bad cholesterol.
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